Oct 17, 2018
In this episode, explore data from the major study proving uric
acid crystals are present in the synovial fluid of patients with
gout, as well as the tale of two rheumatologists who injected their
own knees (while still working in the hospital) with uric acid to
prove it is the trigger for inflammation in gout. The episode
finishes with some ripping yarns about the history of the
medications we use to treat this condition.
- Intro :10
- Controversy surrounding uric acid’s role in gout
- “Game changing” paper published in 1961
- The first description of pseudo gout
- How do you prove uric acid triggered the inflammatory response?
- One of my favorite studies 6:43
- Faires and McCarty inject themselves with uric acid
- Details of what they experienced
- 4 hours later … 8:52
- Both patients receive treatment
- Review of what we’ve discussed so far
- Let’s try and answer the question posited in The History of
Gout, Part 1 10:35
- Colchicine – previously a medicinal plant
- A look at the history of urate-lowering therapy
- Probenecid was developed to reduce the excretion of penicillin
- The history of allopurinol 14:32
- Don’t give allopurinol to patients on azathioprine
- The answer to the question posed in Part 1
- Summary 18:12
We’d love to hear from you! Send your comments/questions to
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Simkin PA. Arthritis Res Ther. 2006;doi:
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Shyambhavee, Behera BK. J Pharmacol Clin Toxicol.
GD. Rheumatology. 2001;40:1189-1190.
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