Oct 5, 2018
Do you know the etymology of the word “gout,” or how a simple microscope aided in the identification of tophi? Join me as I explore the history of this inflammatory arthritis and highlight the important scientists who shaped the modern era of gout.
- Intro :10
- What to expect in Part 2 :48
- A question: Which urate-lowering therapy was made for an expressly different reason than to treat gout? 1:34
- The first modern description of gout 1:54
- Let’s go back to the Greeks 3:05
- Why is it called “gout?” 3:06
- An anecdote from medical school 4:13
- Hippocrates’ words of wisdom on gout 4:58
- First century AD: Gout is linked with excessive eating and drinking 6:01
- Things get muddled 6:20
- 1683: The modern era of gout is described 6:42
- “Gout Perspectives” published in The Lancet in 2018 7:06
- Self-taught Dutch scientist, Antony van Leeuwenhoek, pioneers the microscope and identifies tophi 8:29
- Swedish chemist Carl Wilhelm Scheele discovers uric acid 11:38
- William Hyde Wollaston tests tophi and discovers it’s full of uric acid 12:57
- Emperor of uric acid, Alfred Baring Garrod, associates elevated
serum uric acid with gout 13:48
- If anyone knows how the thread test works, please email me 14:58
- He theorized that uric acid causes gout 15:37
- A look back at what we know 16:09
- What we don’t know: What’s in the joints of patients with acute gout? 16:22
- Stay tuned for The History of Gout, Part 2 16:34
We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com.
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Mccarty DJ, Hollander JL. Ann Intern Med. 1961;54:452-460.
Nuki G, Simkin PA. Arthritis Res Ther. 2006;doi: 10.1186/ar1906.
Rundles RW. Arch Intern Med. 1985;145:1492-1503.
Shyambhavee, Behera BK. J Pharmacol Clin Toxicol. 2017;5:1098.
Storey GD. Rheumatology. 2001;40:1189-1190.
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