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Rheuminations


Oct 15, 2020

The last episode in the series highlighting how the structure of the antibody was discovered, as well as how a chicken butt was critical in understanding B cell biology.

Brought to you by GSK. Consider the long-term impact of disease activity, flares and corticosteroid use on patients with active SLE. Learn more now at treatfortodayandtomorrow.com

  • Intro :11
  • In this episode :15
  • Recap: What we know about the antibody so far 1:12
  • Discovering the structure of the antibody 3:34
  • What else can we learn about the light chain 7:04
  • An understanding of what these proteins were 9:49

Brought to you by GSK. Considering a treatment change for patients with active SLE? Learn about a treatment option for your patients at treatfortodayandtomorrow.com.

  • A story about a chicken butt 11:40
  • Backtracking to 1898 – where do antibodies come from? 16:49
  • An important paper in 1945 argues the lymphocyte is the antibody maker 18:59
  • Where is the bursa of Fabricius in humans? 20:46
  • A study from Australia 21:48
  • The bone marrow is what did it 23:00
  • Thanks for listening! 24:48

Disclosures: Brown reports no relevant financial disclosures.

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

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Cooper MD. Nat Rev Immunol. 2015;191-197.

Edelman GM. J Am Chem Soc. 1959;81:3155-3156.

Ehrich WE, Harris TN. Science. 1945;101:28-31.

Fagraeus A. J Immunol. 1948;58:1-13.

Glick B, et al. Poultry Sci. 1956;35:224-225.

Osmond DG, Nossal GJ. Cell Immunol. 1974;13:132-145.

Porter RR. Biochem J. 1959;73:119-126.

Ryser JE, Vassalli P. J Immunol. 1974;113:719-728.