Nov 27, 2019
Things get a little nerdy in this episode, which focuses on the
basic science of what makes the inflammasome tick in CAPS, as well
as data on the use of interleukin 1 inhibition.
Hint: Listen to “The Inflammasome for Dunces”
episode first, and this one will make more sense.
- Intro :20
- Recap of Part 1 :33
- Overview of this episode 1:56
- Familial cold autoinflammatory syndrome 3:04
- Muckle-Wells syndrome 6:34
- The two checkpoint problem 8:36
- What do we know about the inhibition of the inflammasome? 11:13
- Back to the trebuchet analogy 11:48
Brought to you by GSK. Considering a treatment change for patients with active SLE? Learn about a treatment option for your patients at treatfortodayandtomorrow.com
- A paper on CARD8 in the setting of CAPS 13:50
- Let’s talk about prostaglandins 15:27
- There are over 100 mutations in CAPS 18:15
- Let’s talk about treatment 18:42
- One caveat 25:41
- That’s CAPS 26:45
- Reach out to me via email and on Twitter 27:03
- Episode recap 27:41
We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum
Brought to you by GSK. Consider the long-term impact of disease activity, flares and corticosteroid use on patients with active SLE. Learn more now at treatfortodayandtomorrow.com.
Disclosure: Brown reports no relevant financial disclosures.
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