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Rheuminations


Nov 7, 2019

This first episode delves into the clinical aspects of the Cryopyrin-Associated Periodic Syndromes and includes some helpful tips for sorting out some of the autoinflammatory diseases in the spectrum.

  • Intro :10
  • Cryopyrin-Associated Periodic Syndromes (CAPS) :25
  • Outline of Part 1 2:25
  • What is CAPS? 3:12
  • Case #1 – a 25-year-old female with urticaria after cold exposure 4:25
  • Case #2 – a 55-year-old female with progressive deafness 5:45
  • The index case of familial cold autoinflammatory syndrome 9:00
  • The final disease in the spectrum 11:00
  • A lot of names for the same disease 13:50
  • Genetics prove these three diseases are in the same spectrum 14:22
  • Over 100 mutations have been found to-date 16:31
  • Let’s talk about mosaicism 17:03
  • Disease characteristics of CAPS 18:15
    • Neutrophilic infiltrate in chronic urticaria vs. CAPS 20:00
    • Schnitzler syndrome 20:45
    • Sensorineural hearing loss 21:58
    • Joint pain 24:10
  • Complication: Amyloidosis 25:29
  • These diseases were very debilitating 28:38
  • Episode recap 29:46
  • Part 2 sneak peek 30:38
  • Come say hi at ACR! 30:51

We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

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